Table 1 Sensitivity and specificity of WRN methylation for the diagnosis of CIMP-high

From: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer

 

CIMP-high (≥6/8 methylated promoters)

Non-CIMP-high (≤5/8 methylated promoters)

Total

WRN methylation

 Positive

119 (sensitivity 89%a)

141 (19%)

260

 Negative

14 (11%)

602 (specificity 81%b)

616

Total

133

743

876

  1. Abbreviation: CIMP, CpG island methylator phenotype.
  2. aSensitivity is defined as the number of WRN-positive CIMP-high cases divided by the number of all CIMP-high cases.
  3. bSpecificity is defined as the number of WRN-negative non-CIMP-high cases divided by the number of all non-CIMP-high cases.
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