Table 3 Frequencies of specific molecular features in colorectal cancer according to WRN methylation and CIMP status
Molecular features | Total N | All cases WRN methylation | P-value | CIMP-high WRN methylation | P-value | CIMP-low/0 WRN methylation | P-value | |||
|---|---|---|---|---|---|---|---|---|---|---|
(+) | (−) | (+) | (−) | (+) | (−) | |||||
MSI | ||||||||||
Total examined | 874 | 261 | 613 | 117 | 14 | 125 | 591 | |||
MSI-H | 127 | 89 (34%) | 38 (6.2%) | <0.0001 | 80 (68%) | 10 (71%) | 9 (7.2%) | 27 (4.6%) | ||
MSI-L/MSS | 747 | 172 (66%) | 575 (94%) | 37 (32%) | 4 (29%) | 116 (93%) | 564 (95%) | |||
KRAS | ||||||||||
Total examined | 860 | 254 | 606 | 114 | 14 | 121 | 584 | |||
Mutant | 313 | 96 (38%) | 217 (36%) | 16 (14%) | 2 (14%) | 71 (59%) | 212 (36%) | <0.0001 | ||
Wild-type | 547 | 158 (62%) | 389 (64%) | 98 (86%) | 12 (86%) | 50 (41%) | 372 (64%) | |||
BRAF | ||||||||||
Total examined | 860 | 254 | 606 | 114 | 14 | 121 | 584 | |||
Mutant | 112 | 82 (32%) | 30 (5.0%) | <0.0001 | 68 (60%) | 9 (64%) | 7 (5.8%) | 19 (3.3%) | ||
Wild-type | 748 | 172 (68%) | 576 (95%) | 46 (40%) | 5 (36%) | 114 (94%) | 565 (97%) | |||
18q LOH (only non-MSI-H cases) | ||||||||||
Total examined | 379 | 87 | 292 | 18 | 3 | 59 | 283 | |||
(+) | 235 | 44 (51%) | 191 (65%) | 0.01 | 8 (44%) | 1 (33%) | 33 (56%) | 188 ( (66%) | ||
(−) | 144 | 43 (49%) | 101 (35%) | 10 (56%) | 2 (67%) | 26 (44%) | 95 (34%) | |||
p53 a | ||||||||||
Total examined | 891 | 260 | 631 | 119 | 14 | 123 | 609 | |||
(+) | 386 | 82 (32%) | 304 (48%) | <0.0001 | 27 (23%) | 3 (21%) | 46 (37%) | 298 (49%) | 0.02 | |
(−) | 505 | 178 (68%) | 327 (52%) | 92 (77%) | 11 (79%) | 77 (63%) | 311 (51%) | |||
p21 a | ||||||||||
Total examined | 864 | 252 | 612 | 115 | 14 | 120 | 590 | |||
Loss | 508 | 101 (40%) | 407 (67%) | <0.0001 | 28 (24%) | 3 (21%) | 63 (52%) | 400 (68%) | 0.001 | |
(+) | 356 | 151 (60%) | 205 (33%) | 87 (76%) | 11 (79%) | 57 (48%) | 190 (32%) | |||
