Figure 2
From: Photoexposition discriminates Notch 1 expression in human cutaneous squamous cell carcinoma
Notch 1 is diffusely positive in the epidermis of Bowen's disease (a), irrespective from location (extremities vs face vs trunk). HPV-positive squamous cell carcinomas arising in sun-protected penile skin were all Notch 1 diffusely positive, in both in situ (b) and invasive component (c). Strong and diffuse Notch 1 membrane pattern in an invasive squamous cell carcinomas in sun-protected site (d).
