Figure 2 | Modern Pathology

Figure 2

From: RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi

Figure 2

Detection of MART-1 in FFPE archival melanocytic nevus tissues. (a) IHC reveals that MART-1 (red coloration) is strongly expressed in nevus cells and single melanocyte in the basal layer of the epidermis. (b) By the RT in situ PCR technique, the reaction product of MART-1 mRNA (dark blue to purple coloration) is predominantly located in the cytoplasm of nevus cells, and the nucleus contains less reaction product. Single melanocytes in the basal layer of the epidermis express MART-1 mRNA (arrows).

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