Table 4 Prevalence of HPV as detected by PCR in larger published invasive squamous vulvar carcinoma case series

From: Distribution of human papillomavirus genotypes in invasive squamous carcinoma of the vulva

Ref.

Description/technique

Cases (n)

HPV- positive rate

HPV 16 a

HPV 18 a

HPV 33 a

HPV 45 a

HPV 6 and/or 11 a

Multiple types a

Unclassified types a

40

PCR with Southern blot for HPV types 6, 11, 16, 18, 31, 33, 35, 51, and unclassified

23

30%

4

0

0

NAb

0

0

3

18

PCR with Southern blot for HPV types 6, 11, 16, and 18

22c

54%

10

2

NA

NA

0

HPV16 and 18, one case

NA

34

PCR with dot blot for HPV types 6/11, 16, 18, and 33d

19

31%

13

3

3

NA

0

0

NA

35

PCR with dot blot for HPV types 6/11, 16, 18, and 33

78

31%

21

0

2

NA

0

HPV16 and 33, one case

NA

41

PCR with Southern blot for HPV types 6/11/13/16/18/30/31/32/33/45/51

60

32%

NA

NA

NA

NA

NA

NA

NA

22

PCR with Southern blot for HPV types 6, 16, 18, and unclassified

55

60%

27

3

NA

NA

1

0

2

29

PCR with gel electrophoresis for HPV types 6, 11, 16, 18, 33, and unclassified

74

36%

19

9

1

NA

0

HPV16 and 18, two cases; HPV16 and 33, one case

1

7

PCR with Southern blot for HPV types 6/11, 16, 18/45, 31/33/52, and unclassified

55

51%

24

1

2

1

1

HPV16 and one unclassified, 21 cases; HPV16 and two unclassified, two cases; HPV6/11 and one unclassified, two cases

26

24

PCR with sequence analysis

66

20%

11

0

1

1

0

0

0

31

PCR with dot blot for HPV types 16, 18, 45, 6/11, 31/33/34/35/39, 40/42/43/44/45, and 51/52/54/56/58

158

24%

21

10

0

1

1

HPV16 and 18, four cases; HPV6/11 and 16, one case

NA

2

PCR with gel electrophoresis for HPV types 16, 18, and unclassified

20

85%

9

4

NA

NA

NA

HPV16 & 18, two cases

2

12

PCR with reverse hybridization line probe assay (LiPA) for HPV types 6, 11, 16, 18, 31, 33, 34, 35, 39, 40, 42, 43, 44, 45, 51, 52, 53, 54, 56, 58, 59, 66, 68, 70, and 74

16

0%

0

0

0

0

0

0

NA

27

PCR with sequence analysis

48

60%

19

1

4

0

NA

4

5

Current study

PCR with Linear Array HPV for HPV types 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 5 3, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73, 81, 82, 83, 84, IS39, and CP6108

116

70%

65

2

12

4

3

14

0

  1. aValues for the HPV-positive subcategories do not necessarily sum to the totals because of multiple types identified in individual samples.
  2. bNA, HPV genotype not specifically assessed in study.
  3. cOut of 30 reported invasive squamous vulvar carcinoma cases, eight were negative for both HPV and β-globin control, for a total of 22 cases.
  4. dCocktail probes for detection of multiple HPV types are indicated by a slash between types.
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