Table 4 Results of CGH analysis, FISH, SSCP analysis, and immunohistochemistry in malignant PCC

From: Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas

Samples

Patients

Characteristics

CGH 17p

FISH p53

SSCP

IH

 1

1

F/47 sp/adr/u

•

•

○

○

 2

2

F/65 sp/adr/u

•

•

○

○

 3

3

F/70 sp/adr/u

•

•

○

○

 4

4

F/56 sp/adr/u

•

—

○

—

 5

 

meta

—

—

○

○

 6

5

F/30 sp/ea/u

—

•

—

○

 7

 

Meta intercost I

○

—

○

•

 8

 

Meta intercost II

•

•

○

—

 9

6

M/70 sp/adr/u

—

—

—

○

10

 

Meta LN

•

•

○

—

11

7

F/53 sp/ea/u

—

—

—

○

12

 

Meta

○

—

○

○

13

8

F/27 sp/adr/u

○○

○○

○

○

14

9

F/32 sp/adr/u

○

—

○

—

15

 

Meta LN I

○

○

○

○

16

 

Meta LN II

○

—

○

—

17

10

M/32 sp/ea/u

○

○

○

○

18

11

M/36 sp/adr/u

○

○

○

○

19

 

Meta LN

—

—

○

○

20

12

F/23 sp/adr/u

○

○

○

—

21

 

Meta bone

—

—

○

•

22

13

F/62 sp/adr/u

○

○

○

○

23

14

M/42 sp/adr/u

○

—

○

—

24

15

M/42 sp/adr/u

—

—

○

—

25

16

F/39 sp/adr/u

—

—

○

○

26

 

/49 meta LN

○

—

○

—

27

17

F/45 sp/adr/u

○

—

○

—

28

 

Meta LN

—

○

—

—

29

18

F/32 sp/adr/u

—

—

○

—

30

 

Meta liver

○

—

○

—

  1. In CGH analysis, ○ represents ‘no gain or loss,’ • is ‘loss,’ and ○○ means ‘gain’ of chromosome 17. In FISH analysis, ○ is ‘retention of heterozygosity,’ • means ‘loss of heterozygosity,’ and ○○ represents ‘gain’ of the p53 locus on chromosome 17. In SSCP, ○ means no mutation. In immunohistochemistry, ○ represents ‘no overexpression’ and • means p53 protein overexpression. In all four techniques, — means that these samples are not examined. M=male; F=female; sp=sporadic; m=men; n=neurofibromatosis; adr=adrenal; ea=extra-adrenal; u=unilateral; bi=bilateral; Meta=metastasis; LN=lymph node.
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