FIGURE 1

Tenascin (TN) immunoreactivity in gliomas (immunohistochemistry with anti-TN/3,3′-diaminobenzidine). A, glioblastoma. TN (light brown) is expressed in the walls and in the basement membrane zone of proliferating glomeruloid stromal blood vessels, 200 ×. B, TN-positive stromal blood vessels surround an area of tumor necrosis (N), 200 ×. C, TN is located around and between the tumor cells as well as in the cytoplasm of some of the tumor cells (arrowheads), 200 ×. D, diffuse intervascular and intercellular TN expression, 100 ×. E, intense diffuse TN expression in the extracellular matrix between the tumor cells in an oligoastrocytoma, 200 ×. F, glioblastoma (brownish-red) infiltrating brain cortex. Diffuse TN expression (light brown) is present in the neuropil surrounding the tumor cells (double immunohistochemistry: anti-TN/3,3′-diaminobenzidine + anti–glial fibrillary acidic protein/3-amino-9-ethylcarbazole), 200 ×.