TABLE 2 Size, Ki67, and Metastatic Disease in Hurthle Cell Carcinomas with and without Vascular Invasion

From: Pathologic Features, Proliferative Activity, and Cyclin D1 Expression in Hurthle Cell Neoplasms of the Thyroid

Vascular Invasion

N

Tumor Size (cm) (mean ± SEM)

Ki67 Labeling Index (mean ± SEM)

Metastatic Disease

Absent

9

2.5 ± 0.3

4.5 ± 1.0

0

Present

46

5.3 ± 0.4a

11.0b ± 1.4

19c

  1. SEM, standard error of the mean.
  2. aHurthle cell carcinomas with vascular invasion were significantly larger than those without vascular invasion (p =.0017).
  3. bHurthle cell carcinomas with vascular invasion had a significantly higher K167 labeling index than those without vascular invasion (p =.0174).
  4. cMetastatic disease was seen in 19 Hurthle cell carcinomas with vascular invasion but in no tumors with only capsular invasion (p =.011).
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