FIGURE 18
From: Problems in the Differential Diagnosis of Endometrial Hyperplasia and Carcinoma

Well-differentiated adenocarcinoma in which the intervening stroma between glands has been converted to lipid-laden foam cells. Elsewhere in the specimen, a more typical desmoplastic stroma was present. Note that some of the malignant glands in this field reveal mucinous degeneration, but the foam cell change is a good indicator that the tumor is primary in the endometrium rather than in the endocervix.