FIGURE 21
From: Problems in the Differential Diagnosis of Endometrial Hyperplasia and Carcinoma
High-grade endometrioid adenocarcinoma with squamous differentiation, mixed adenosquamous carcinoma type. Distinction between the solid adenocarcinomatous component seen in the lower left and the malignant squamous elements seen at the top and right is difficult, but the squamous components show sheet-like growth, sharp cell margins, eosinophilic and glassy cytoplasm, and increased amounts of cytoplasm (thus, a lower nuclear:cytoplasmic ratio) compared with the malignant glandular component. In this field, only the glandular component would be graded, and this would be considered FIGO Grade 3.
