TABLE 1 p53 Mutation Spectrum in Gastric Cancer
Tumor | Exon/Codon | Base Substitution | Type | Consequence |
|---|---|---|---|---|
1 | 8 bp splice-donor exon 6 | G to A | Splicing? | |
2 | 5/185 | Insertion TA | Frame shift | Stop in exon 7 |
3 | 4/52 | Insertion CAT | In frame | + His |
4 | 5/175 | CGC to CAC | Missense | Arg to His |
5 | 8/295 | CGG to TGG | Missense | Arg to Trp |
6 | 8/272 | GTG to GCG | Missense | Val to Ala |
7 | 8/280 | AGA to AAA | Missense | Arg to Lys |
8 | 7 bp splice-donor exon 5 | C to T | Splicing? | |
9 | 6/192 | CAG to TAG | Missense | Stop |
