TABLE 1 Summary of Reports on HPV Infection in Oral Mucosaa

From: “High Risk” HPV Types Are Frequently Detected in Potentially Malignant and Malignant Oral Lesions, But Not in Normal Oral Mucosa

Study

References

Country

Year

Normal Samples

Pathologic Specimens

HPV Positive

Infection by Typesb

Detection Methods

     

Hyperpl

Dyspl

Oral SqCC

 

2

6

11

16

18

33

58

Otherc

SB

PCR

DB

ISH

RFLP

SEQ

IHC

EM

North America

                        

 Holladay & Gerald

10

USA

1993

6 (17%)

9 (44%)

36 (25%)

39 (18%)

20 (24%)

 

11

 

21

1

   

+

+

      

 Woods et al.

11

USA

1993

9 (67%)

–

–

18 (78%)

14 (78%)

 

4

1

7

2

    

+

      

 Brandwein et al.

12

USA

1994

–

–

–

64 (25%)

16 (25%)

         

+

      

 Paz et al.

13

USA

1997

–

–

–

92 (20%)

18 (20%)

 

2

 

13

   

3

+

+

      

 Portugal et al.

14

USA

1997

–

–

–

58 (7%)

4 (7%)

         

+

      

 Wilczynski et al.

15

USA

1998

–

–

–

19 (63%)

12 (63%)

   

9

 

1

 

2

+

+

 

+

+

   

South America

                        

 Miguel et al.

16

Brazil

1998

34 (12%)

–

–

34 (12%)

4 (12%)

   

4

     

+

+

+

    

 Premoli-De-Percoco et al.

8

Venezuela

1998

–

–

–

50 (70%)

35 (70%)

 

7

 

28

       

+

    

Africa

                        

 Van Rensburg et al.

17

South Africa

1995

–

–

–

66 (0%)

0 (0%)

           

+

  

+

 

Asia

                        

 Chang et al.

18

China

1989

17 (6%)

3 (100%)

–

17 (76%)

16 (80%)

   

16

    

+

       

 Heinzel et al.

19

India

1996

–

–

–

91 (74%)

67 (74%)

                

 Chatterjee et al.

20

India

1997

–

–

–

39 (69%)

26 (69%)

   

19

       

+

    

 D'Costa et al.

3

India

1998

48 (31%)

–

80 (34%)

100 (15%)

42 (23%)

   

42

    

+

+

      

 Wen et al.

21

Japan

1997

–

15 (33%)

–

45 (33%)

16 (32%)

   

16

12

   

+

+

   

+

  

 Mineta et al.

22

Japan

1998

–

–

–

14 (21%)

3 (21%)

   

3

     

+

      

 Shinji et al.

23

Japan

1999

7 (0%)

–

–

15 (0%)

0 (0%)

        

+

+

      

 Koh et al.

24

Korea

1998

–

–

–

42 (52%)

22 (52%)

   

13

5

4

  

+

+

      

Europe

                        

 Cerovac et al.

25

Croatia

1996

–

–

–

25 (20%)

5 (20%)

           

+

    

 Eike et al.

26

Denmark

1995

61 (0%)

–

–

–

–

         

+

      

 Syrjanen et al.

27

Finland

1983

–

–

–

40 (40%)

16 (40%)

              

+

+

 Atula et al.

28

Finland

1997

–

–

–

41 (20%)

8 (20%)

   

4

    

+

+

      

 Fouret et al.

29

France

1995

42 (0%)

–

3 (0%)

21 (8%)

2 (8%)

        

+

+

      

 Gassenmaier & Hornstein

30

Germany

1988

–

202 (10%)

103 (18%)

68 (24%)

56 (15%)

4

6

7

12

       

+

    

 Honig

31

Germany

1992

–

–

–

12 (60%)

7 (60%)

           

+

    

 Ostwald et al.

32

Germany

1994

97 (1%)

–

–

26 (61.5%)

16 (61.5%)

        

+

+

      

 Arndt et al.

33

Germany

1997

–

14 (86%)

1 (100%)

–

13 (87%)

 

13

 

3

    

+

+

      

 Riethdorf et al.

34

Germany

1997

–

–

–

80 (44%)

35 (44%)

         

+

+

     

 Andl et al.

35

Germany

1998

–

–

–

64 (17%)

11 (17%)

   

8

 

1

  

+

+

      

 Lambropoulos et al.

36

Greece

1997

169 (9.5%)

–

–

–

–

 

7

1

4

    

+

+

      

 Present study

 

Greece

1999

16 (0%)

29 (86%)

5 (100%)

19 (95%)

48 (90%)

 

7

1

34

17

6

3

  

+

+

+

+

   

 Lo Muzio et al.

37

Italy

1997

–

–

21 (48%)

5 (40%)

17 (66%)

 

3

 

9

       

+

    

 Cruz et al.

38

Netherlands

1996

–

–

–

35 (54%)

19 (54%)

 

1

 

15

   

4

+

+

      

 Snijders et al.

39

Netherlands

1996

–

–

–

25 (20%)

5 (20%)

   

5

    

+

+

      

 Matzow et al.

40

Norway

1998

–

5 (0%)

–

35 (3%)

1 (3%)

       

1

 

+

      

 Adams et al.

41

Switzerland

1999

4 (50%)

–

–

20 (30%)

6 (30%)

   

5

1

    

+

  

+

   

 Jalal et al.

42

UK

1992

48 (44%)

–

–

–

–

   

21

     

+

      

 Scholes et al.

43

UK

1997

–

–

–

8 (62%)

5 (62%)

   

5

    

+

+

      

 Elamin et al.

44

UK

1998

–

–

12 (33%)

28 (50%)

18 (45%)

 

8

 

10

     

+

      

 Penhallow et al.

45

UK

1998

–

3 (67%)

9 (56%)

28 (50%)

18 (53%)

 

8

 

10

     

+

      
  1. HPV, human papillomavirus; Hyperpl, hyperplasia; Dyspl, dysplasia; SqCC, squamous cell carcinoma; SB, Southern or slot blot; PCR, polymerase chain reaction; DB, dot blot; ISH, in situ hybridization; RFLP, restriction fragment length polymorphism; SEQ, sequencing; IHC, immunohistochemistry; EM, electron microscopy.
  2. aStudies analyzing fewer than 10 samples were not included in this table.
  3. bDetected either alone or in combination with other types.
  4. cType determination not achieved by applied methodology.
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