TABLE 1 Ki-67, ER, PR, p53, and c-erb-B-2 Status: Comparison Between Cytoblocks and Tissues

From: Immunohistochemistry on Cell Blocks From Fine-Needle Cytopunctures of Primary Breast Carcinomas and Lymph Node Metastases

Cytoblocks

Positive Cells (%)

Tissue Sections (n = 55)

Concordance

  

−

+

++

 

Ki-67−

<20

30

4

  

Ki-67+

≥20

4

17

 

47/55 (85.4%)a

ER−

<10

9

0

1

 

ER+

10–49

0

2

5

53/55 (96.3%)a

ER++

≥50

1

1

36

47/55 (85.5%)b

PR−

<10

12

5

1

 

PR+

10–49

4

10

6

45/55 (81.8%)a

PR++

≥50

0

0

17

39/55 (70.9%)b

p53−

<10

17

2

0

 

p53+

10–49

10

13

2

42/55 (76.4%)a

p53++

≥50

1

2

8

38/55 (69.1%)b

c-erb-B-2−

<10

15

5

4

 

c-erb-B-2+

10–49

0

6

7

46/55 (83.6%)a

c-erb-B-2++

≥50

0

2

16

37/55 (67.3%)b

  1. ER, estrogen receptors; PR, progesterone receptors; −, negative; +, positive, ++, highly positive (≥50%).
  2. aTwo-group classification (− versus + and ++).
  3. bThree-group classification.
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