TABLE 1 Comparison of WHO/ISUP Grade and Stage with Clinical Data in 120 Papillary Urothelial pTa and pT1 Urothelial Neoplasms

From: Relationship of Cytokeratin 20 and CD44 Protein Expression with WHO/ISUP Grade in pTa and pT1 Papillary Urothelial Neoplasia

WHO/ISUP grade

Pap

LMP

LG

HG

Total

P-value

Stage

 pTa

100% (8)

100% (8)

97.6% (41)

50% (31)

73.3% (88)

<0.005

 pT1

0

0

2.4% (1)

50% (31)

26.7% (32)

 

Total % (no. of cases)

6.7% (8)

6.7% (8)

35% (42)

51.7% (62)

100% (120)

 

Mean age (yrs)*

42.8

53.4

64.5

65.6

62.9

<0.005

Sex (M:F) ratio

3:1

1:1.7

7.4:1

7.9:1

5.3:1

 

Recurrence**

0

33.3%

64.1%

56.4%

54.7%

0.02

Progression in stage***

0

0

10.5%

27.1%

17.3%

0.031

 pTa to pT1

0

0

2.6%

8.3%

8.6%

 

 Muscle invasion

0

0

5.3%

6.3%

5.1%

 

 Metastasis

0

0

5.3%

8.3%

6.1%

 

 Death from disease

0

0

5.3%

16.7%

10.2%

 
  1. Pap, papilloma; LMP, papillary urothelial neoplasm of low malignant potential; LG, low-grade papillary urothelial carcinoma; HG, high-grade papillary urothelial carcinoma.
  2. *Analyzed as Pap and LMP vs. LG and HG or Pap, LMP and LG vs. HG.
  3. **Data available for tumor recurrence in 106 of 120 cases.
  4. ***Data available for tumor progression in 98 of 120 cases. Data analyzed as Pap and LMP vs. LG vs. HG.