FIGURE 1 | Modern Pathology

FIGURE 1

From: In Situ Hybridization and Reverse Transcription–Polymerase Chain Reaction for Cyclin D1 mRNA in the Diagnosis of Mantle Cell Lymphoma in Paraffin-Embedded Tissues

FIGURE 1

Histologic and immunohistochemical findings. A, low-power view of a lymph node infiltrated by mantle cell lymphoma (MCL), centrocytoid type. A vaguely nodular pattern can be seen. Original magnification, 100×. B, high-power view showing a monotonous population of MCL cells. Original magnification, 400×. C, positive nuclear immunostaining for cyclin D1 is present in the neoplastic lymphoid cells, whereas the germinal center cells are negative. Original magnification, 400×.

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