FIGURE 1 | Modern Pathology

FIGURE 1

From: Epstein-Barr Virus–Negative Hodgkin's Lymphoma After Mycosis Fungoides: Molecular Evidence for Distinct Clonal Origin

FIGURE 1

Histopathologic and immunohistochemical features. (A) Mycosis fungoides: band-like subepidermal and focally epidermotropic lymphoid infiltrates. Note the characteristic intraepidermal cluster of lymphocytes (Pautrier microabscess); the inset shows atypical intraepidermal lymphocytes, H&E staining, magnification ×1000. (B) Microphotograph of the epidermal-subepidermal junction with intraepidermal lymphocytes and haloed lymphocytes in the basal layer, magnification ×600. (C–E) Bone marrow: lymphoid infiltrate consisting of small lymphocytes with scattered large mononuclear and binucleated cells (C); the inset shows typical Hodgkin and RS cells, magnification ×400. The Hodgkin and RS cells show a strong membrane staining for (D) CD15 and (E) CD30. Magnification of Panels D and E: ×300.

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