FIGURE 5 | Modern Pathology

FIGURE 5

From: Characterization of NF-κB Expression in Hodgkin’s Disease: Inhibition of Constitutively Expressed NF-κB Results in Spontaneous Caspase-Independent Apoptosis in Hodgkin and Reed-Sternberg Cells

FIGURE 5

The effect of various caspase inhibitors (100 μM) on CD95-induced apoptosis in sensitive classical Hodgkin’s disease cell lines. For both HS445 and L428, each caspase inhibitor produced a significant, and often marked, decrease in CD95-induced apoptosis, demonstrating the importance of caspase proteases in mediating CD95-induced apoptosis. These data show the mean increase in apoptosis ± SE from three separate experiments.

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