FIGURE 8 | Modern Pathology

FIGURE 8

From: Characterization of NF-κB Expression in Hodgkin’s Disease: Inhibition of Constitutively Expressed NF-κB Results in Spontaneous Caspase-Independent Apoptosis in Hodgkin and Reed-Sternberg Cells

FIGURE 8

Caspase-3 activity in classical Hodgkin’s disease cell lines treated with MG132, gliotoxin, or anti-CD95 mAb after 48-hour incubation. No significant increases in caspase-3 function activity were detected in all three cell lines after 48 hours of MG132 or gliotoxin treatment. As expected, significant increases in caspase-3 functional activity were obtained in the CD95 sensitive cell lines (HS445 and L428) after 48-hour treatment with agonistic CD95 mAb. Values are the means ± SE from three separate experiments.

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