FIGURE 3 | Modern Pathology

FIGURE 3

From: Fine-Needle Aspiration Biopsy in the Diagnosis and Classification of Primary and Recurrent Lymphoma: A Retrospective Analysis of the Utility of Cytomorphology and Flow Cytometry

FIGURE 3

A, Diffuse large, B-cell lymphoma. Cytology smears show a dispersed population of large, malignant lymphoid cells with clumped chromatin, prominent nuclei, and variably stripped cytoplasm (Papanicolaou stain; 900×). B, Marginal-zone lymphoma. In this extranodal example, cytology smears demonstrate salivary gland acini (lower left) associated with a polymorphous population of small, only slightly atypical lymphoid cells. Marginal-zone cells, characterized by a rim of clear cytoplasm, are visible but may be difficult to appreciate in wet fixed preparations (Papanicolaou stain; 900×). C, Anaplastic large-cell lymphoma. Cytology smears show large, anaplastic tumor cells with prominent nuclei in a cohesive cluster, a feature that can cause confusion with non-hematopoietic malignancies (Papanicolaou stain; 900×). D, Hodgkin's disease. Cytology smears that demonstrate typical Reed-Sternberg cells are diagnostic (Papanicolaou stain; 560×).

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