FIGURE 1
From: Expression of Apocrine Differentiation Markers in Neuroendocrine Breast Carcinomas of Aged Women
Expression of ChA and GCDFP-15 in different histotypes of NE breast cancers (mucinous, solid papillary, and solid cohesive types). A cribriform sheet of cells is floating within the mucin lakes in a mucinous NE–apocrine carcinoma (A). The same tumor is positive for ChA (B) and GCDFP-15 (C) in >50% of cells. In a solid papillary carcinoma, a solid nest of cells (upper) is separated from a mucin-producing area by sclerotic stroma (D). ChA is expressed only in the mucinous component (E), whereas GCDFP-15 is expressed in both counterparts (F). Solid cohesive NE–apocrine carcinoma showing rosettelike structures and peripheral cell palisading are reminiscent of carcinoid tumors (G). Both ChA (H) and GCDFP-15 (I) are expressed.
