TABLE 1 Relationship between hTERT Expression† and Clinicopathologic Findings in 125 Cases

From: Expression of Telomerase Catalytic Subunit (hTERT) mRNA Does Not Predict Survival in Patients with Transitional Cell Carcinoma of the Upper Urinary Tract

 

All tumors (n = 125)

Noninvasive Tumors (n = 48)

Invasive Tumors (n = 77)

Correlative Data

No. of Cases

Expression of hTERT

P Value

No. of Cases

Expression of hTERT

P Value

No. of Cases

Expression of hTERT

P Value

  

High Score

Low Score

  

High Score

Low Score

  

High Score

Low Score

 

Age (y)

            

 ≤67

64

19

45

0.98‡

25

11

14

0.33‡

39

8

31

0.39‡

 >67

61

18

43

 

23

7

16

 

38

11

27

 

Sex

            

 Male

89

30

59

0.11‡

37

15

22

0.42‡

52

15

37

0.22‡

 Female

36

7

29

 

11

3

8

 

25

4

21

 

Stage*

            

 Group A

48

18

30

0.12‡‡

48

18

30

     

 Group B

19

6

13

     

19

6

13

0.42‡‡

 Group C

58

13

45

     

58

13

45

 

Grade

            

 Low

74

21

53

0.71‡

42

14

28

0.11‡

32

7

25

0.63‡

 High

51

16

35

 

6

4

2

 

45

12

33

 

Pattern of growth

            

 Papillary

87

28

59

0.33‡

48

18

30

 

39

10

29

0.84‡

 Nonpapillary

38

9

29

     

38

9

29

 

PCNA index

            

 <69%

62

21

41

0.29‡

30

12

18

0.64‡

32

9

23

0.55‡

 ≥69%

63

16

47

 

18

6

12

 

45

10

35

 
  1. PCNA, proliferating cell nuclear antigen index.
  2. hTERT scores were classified as “high score” if the score was ≥5 because 4 was the median value for the carcinomas studied. The extent of staining was scored as 1, indicating 10–33% of tumor area stained; 2, 34–66% stained; or 3, >67% stained. Intensity of staining was scored as 1, indicating weak; 2, moderate; or 3, strong. These two scores were summed to give in each case a final score (ranging from 0 to 6).
  3. *The tumors were divided into three groups: Group A (papillary, noninvasive tumors, pTa); Group B (tumors invading the submucosa or muscularis, pT1 and pT2); and Group C (tumors invading beyond the muscularis or renal parenchyma or metastasizing the regional lymph node or a distant site, pT3 and pT4).
  4. ‡Comparisons with respect to age, sex, grade, pattern of growth, and proliferating nuclear cell antigen were performed using the chi-square analysis.
  5. ‡‡Comparisons with respect to stage were performed using Mann-Whitney U test.
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