FIGURE 3 | Modern Pathology

FIGURE 3

From: p53 Alteration and Chromosomal Instability in Prostatic High-Grade Intraepithelial Neoplasia and Concurrent Carcinoma: Analysis by Immunohistochemistry, Interphase In Situ Hybridization, and Sequencing of Laser-Captured Microdissected Specimens

FIGURE 3

p53 sequencing analysis. Top picture, a normal sequence of Exon 8. Middle picture, a wild-type p53 (Patient 9). Bottom picture, mutated p53 with a change in Codon 273, changing the wild-type TGC to TGT and changing the amino acid from arginine to cystine. The corresponding IHC for p53 is on the left side.

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