TABLE 4 Separation of CSS from Other ANCA-Positive Vasculitides
From: Recent Advances in the Diagnosis of Churg-Strauss Syndrome
Finding | CSS | Wegener's Granulomatosis | Microscopic Polyangiitis |
|---|---|---|---|
Fundamental histology | Eosinophilic tissue infiltrates and vasculitis; granulomas have eosinophilic necrosis | Vasculitis with PMNs; granulomatous necrosis is basophilic | Vasculitis with PMNs; no granulomatous reaction |
ANCA | ≤70% of cases; usually p-ANCA | 90% of cases in some series; usually c-ANCA | Up to 80% of cases; usually p-ANCAm |
Allergic rhinitis | Most cases | Rare | Rare |
Asthma | Almost always present by time of vasculitic phase | Uncommon | Uncommon |
Eosinophilia | Almost always present by time of vasculitic phase | Occasionally low level | Very unusual (most such cases turn out to be CSS) |
Cardiac disease | Common and life-threatening | Uncommon | Uncommon |
Renal failure | Uncommon | Common and rapidly progressive | Common and rapidly progressive |
Mononeuritis multiplex | Present in most cases | Occasional | Occasional |
Skin lesions | Common | Occasional | Common |
