TABLE 4 Summarized Patterns of Genetic Changes on Chromosome 8 in Stage T_2–3N_1–3M₀ Prostate Cancer

Patterns	8p^a	CEP8	c-myc	Number of Cancer Foci (%)		P Value^b	Number of Patients in Each Group (%)		P Value^c
				Primary	Metastasis		Case	Control
1	Normal	Normal	Normal	6 (5)	1 (1)	.048	1 (4)	1 (4)	1.00
2	Loss	Normal	Normal	22 (18)	14 (12)	.45	2 (8)	4 (15)	.42
3	Loss	Loss	Normal	3 (3)	2 (2)	.57	0 (0)	0 (0)	—
4	Loss	Gain	Gain	45 (38)	63 (55)	.25	8 (31)	11 (42)	.37
5	Gain	Gain	Gain	6 (5)	1 (1)	.07	1 (4)	3 (12)	.34
6	Loss	Loss	Loss	2 (2)	0 (0)	—	0 (0)	1 (4)	.99
7	Normal	Normal	AI	4 (3)	1 (1)	.07	0 (0)	0 (0)	—
8	Loss	Normal	AI	7 (6)	8 (7)	.83	6 (23)	0 (0)	.10
9	Loss	Loss	AI	5 (4)	3 (3)	.81	1 (4)	2 (8)	.57
10	Loss	Gain	AI	18 (15)	14 (12)	.81	7 (26)	3 (12)	.21
11	Gain	Gain	AI	1 (1)	7 (6)	.08	0 (0)	0 (0)	—
Total				119 (100)	114 (100)		26 (100)	26 (100)

^aLoss of 8p in this table includes −8p and relative −8p (see definition in “Results”).
^bComparing primary tumor versus lymph node metastasis using GEE models.
^cComparing case group versus control group using conditional logistic regression.

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