TABLE 5 Summarized Patterns of Genetic Changes on Chromosomes 7, 8, and 17 in Stage T2–3N1–3M0 Prostate Cancer

From: Loss of p53 and c-myc Overrepresentation in Stage T2-3N1-3M0 Prostate Cancer are Potential Markers for Cancer Progression

Patterns

Combined Genetic Changes

Number of Cancer Foci (%)

P Valuea

Number of Patients in Each Group (%)

P Valueb

  

Primary

Metastasis

 

Case

Control

 

I

−8p, +c-myc or AI-myc, +7q

23 (21)

28 (27)

.54

4 (18)

7 (32)

.27

II

−8p, +c-myc or AI-myc, +7q, −p53

12 (11)

13 (13)

.75

6 (27)

2 (9)

.18

III

−8p, +c-myc or AI-myc, +7q, +p53

6 (6)

22 (21)

.08

0 (0)

3 (14)

.99

IV

Other 16 patterns

65 (60)

40 (39)

.06

12 (55)

10 (45)

.53

Totalc

 

108 (100)

103 (100)

 

22 (100)

22 (100)

 
  1. aComparing primary tumor versus lymph node metastasis using GEE models.
  2. bComparing case group versus control group using conditional logistic regression.
  3. cBecause there was not enough tissue, FISH analysis of Chromosome 7 was not performed on all foci and cases.
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