TABLE 4 Differentiating Autoimmune Gastritis (AG) from H. pylori Gastritis

From: Autoimmune Gastritis: Distinct Histological and Immunohistochemical Findings Before Complete Loss of Oxyntic Glands

Feature

AG

H. Pylori Gastritis

Nature of inflammatory infiltrate

Diffuse or patchy lymphoplasmacytic infiltration of lamina propria, often with deep predominance

Often a bandlike infiltrate that is oriented more superficially and frequently shows activity

Gland destruction

Frequent

Infrequent

Parietal cell hyperplasia/hypertrophy

Frequent

Infrequent (unless on proton pump inhibitors)

ECL cell hyperplasia (at least linear)

Frequent

Infrequent

Predominantly affected part of stomach

Body

Antrum and body

Predominant location of metaplasia

Body (intestinal/pyloric)

Antrum (intestinal)

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