FIGURE 1 | Modern Pathology

FIGURE 1

From: Immunohistochemical Detection of Hepatocellular Carcinoma in the Setting of Ongoing Necrosis after Radiofrequency Ablation

FIGURE 1

Surgically resected hepatocellular carcinoma (HCC) 4 weeks after RF therapy. A, nonablated HCC consisted of viable cells with occasional intercytoplasmic bile pigments. Hematoxylin and eosin stain (HE), 200×. B, HCC with cytoplasmic eosinophilia and intense nuclear chromatin staining was considered to be ongoing necrosis. Note the obscured cytoplasmic border. HE, 200×. C, Complete necrosis of HCC. HE, 200×. D, viable HCC negative for ssDNA immunostaining; counterstained with hematoxylin. 200×. E, nuclei in ongoing necrosis were labeled with ssDNA. 200×. F, nuclei in complete necrosis were negative for ssDNA. 200×.

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