FIGURE 2 | Modern Pathology

FIGURE 2

From: Aneusomy 17 in Breast Cancer: Its Role in HER-2/neu Protein Expression and Implication for Clinical Assessment of HER-2/neu Status

FIGURE 2

Comparison of distribution patterns of chromosome 17 copy number and HER-2/neu gene copy number. The cases (open circles) are plotted based on the respective chromosome 17 copy number (signals per cell) and HER-2/neu gene copy number (signals per cell). Both variables are drawn in the same scale. Solid line represents the PathVysion cutoff for gene amplification (HER-2/neu gene to chromosome 17 ratio, 2.00). The other two lines represent the respective HER-2/neu gene to chromosome 17 ratios of 1.00 (dashed line) and 4.00 (dashed line). A, all 189 cases. B, the cases with no HER-2/neu protein expression (Automated Cellular Imaging System immunohistochemistry scores of <2.0). C, the cases with HER-2/neu protein expression (ACIS scores of ≥2.0).

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