TABLE 3 Kappa Indices for Intraobserver Agreement between Readings by Digitalized Images and Microscopic Slides

Readings by Pathologist	Individual Kappa	P	95% Confidence Interval	Interpretation^a
Pathologist 1
Negative	0.78	<0.001^*	0.47–1.00	Excellent
Indefinite	0.47	0.004^*	0.15–0.79	Fair
LGD	0.73	<0.001^*	0.41–1.00	Good
HGD	0.91	<0.001^*	0.59–1.00	Excellent
Overall	0.50	<0.001^*	0.54–0.93	Good
Pathologist 2
Negative	0.62	<0.001^*	0.30–0.93	Good
Indefinite	−0.16	0.310	−0.48–0.15	Poor
LGD	0.01	0.940	−0.30–0.33	Poor
HGD	0.42	<0.010^*	0.10–0.74	Fair
Overall	0.22	<0.018^*	0.04–0.41	Poor
Pathologist 3
Negative	0.67	<0.001^*	0.35–0.99	Good
Indefinite	0.52	0.001^*	0.21–0.84	Good
LGD	0.75	<0.001^*	0.44–1.00	Excellent
HGD	0.76	<0.001^*	0.43–1.00	Excellent
Overall	0.68	<0.001^*	0.49–0.87	Good
Pathologist 4
Negative	0.52	0.001^*	0.21–0.84	Good
Indefinite	0.19	0.250	−0.13–0.50	Poor
LGD	0.37	0.024^*	0.05–0.68	Poor
HGD	0.27	0.100	−0.05–0.59	Poor
Overall	0.33	<0.001^*	0.14–0.51	Poor

LGD, = low-grade dysplasia; HGD, = high-grade dysplasia.
^*Significant agreement beyond chance.
^aPoor: kappa < 0.40, fair to good: 0.40 ≤ kappa ≤ 0.75, excellent: kappa > 0.75.

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