FIGURE 2 | Modern Pathology

FIGURE 2

From: Infrequent p53 Gene Mutations and Lack of p53 Protein Expression in Clear Cell Sarcoma of the Kidney: Immunohistochemical Study and Mutation Analysis of p53 in Renal Tumors of Unfavorable Prognosis

FIGURE 2

DNA sequencing analysis of p53 gene in tumor samples of clear cell sarcoma of the kidney. DNA sequencing revealed the following: an A → G transition, upstream 9th base from codon 225, in intron (Case 4), a T insertion between codons 162 and 163 (Case 6), and a C → T transversion in codon 289 (Case 7). Cases 4 and 6 showed the sense strand of the p53 gene. Case 7 showed the antisense strand of the p53 gene.

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