TABLE 3 Clinicopathologic Features of Hybrid Carcinomas of the Salivary and Lacrimal Glands

From: Hybrid Carcinomas of the Salivary Glands: Report of Nine Cases with a Clinicopathologic, Immunohistochemical, and p53 Gene Alteration Analysis

Case No.

Age (y)

Gender

Site

Size (cm)

Histology

Proportiona (%)

Therapy

Metastasis

Follow-up

1

74

F

R. parotid

10

1) EMC

70

TP + RT

NED at 10 mo

     

2) BCAC (solid type)

30

   

2

56

M

L. parotid

2

1) EMC

60

SP + RND + RT

NED at 2 y, 7 mo

     

2) BCAC (solid type)

40

   

3

73

F

L. parotid

2

1) EMC

60

SP

NED at 4 y

     

2) Keratinizing SCC

40

   

4

40

M

R. parotid

3

1) SDC)

80

SP + RT

NED at 15 y

     

2) AdCC

20

   

5

81

F

R. submandibular

3

1) SDC

80

TG + RND + RT

LN+

Lost

     

2) AdCC

20

   

6

65

M

R. parotid

5

1) MC (clear-cell type)

90

TP + RND + RT

LN+

AWD at 4 mo

     

2) SDC

10

   

7

42

M

L. parotid

4

1) ACC (microcystic variant)

70

SP

Lost

     

2) SDC

30

   

8

66

M

R. parotid

3.5

1) Keratinizing SCC

80

TP + RND + RT

LN+

AWD at 1 y, 8 mo

     

2) SDC

20

   

9

64

F

R. lacrimal

5

1) Keratinizing SCC

70

Excision

NED at 7 mo

     

2) SDC

30

   
  1. F, female; R, right; EMC, epithelial–myoepithelial carcinoma; TP, total parotidectomy; RT, radiation therapy; NED, no evidence of disease; BCAC, basal cell adenocarcinoma; M, male; L, left; SP, superficial parotidectomy; RND, radical neck dissection; TG, total glandectomy; SCC, squamous cell carcinoma; SDC, salivary duct carcinoma; AdCC, adenoid cystic carcinoma; MC, myoepithlial carcinoma; AWD, alive with disease; LN, lymph node; ACC, acinic cell carcinoma.
  2. aApproximate proportion of the area of the area of the each carcinomatous component in the tumor mass (%).