FIGURE 3 | Modern Pathology

FIGURE 3

From: Immunohistochemical Pattern of MLH1/MSH2 Expression Is Related to Clinical and Pathological Features in Colorectal Adenocarcinomas with Microsatellite Instability

FIGURE 3

Disease-specific survival of colorectal cancer patients by microsatellite instability status and MLH1/MSH2 immunostaining. Among high-frequency microsatellite instability (MSI-H) tumors, patients with MLH1-negative carcinomas more often died of disease than did patients with MLH1/MSH2-positive and MSH2-negative carcinomas, but the differences in survival between the three groups of patients were not statistically significant. Patients with low-frequency microsatellite instability (MSI-L) or microsatellite stable (MSS) tumors showed a less favorable clinical outcome with respect to all patients with MSI-H carcinomas (P = .0041).

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