TABLE 3 Relationship Between MLH1/MSH2 Immunostaining Pattern and Family History of Colorectal Cancer among Patients with MSI-H Large Bowel Carcinomas

From: Immunohistochemical Pattern of MLH1/MSH2 Expression Is Related to Clinical and Pathological Features in Colorectal Adenocarcinomas with Microsatellite Instability

Family History of Colorectal Cancer

No. of Patients (%)

Pattern of Immunoreactivity (%)

  

MLH1 Negative

MSH2 Negative

MLH1/MSH2 Positive

HNPCC or suspected HNPCC

10 (7.9)

5 (50.0)

3 (30.0)

2 (20.0)

Positive

14 (11.0)

10 (71.4)

1 (7.2)

3 (21.4)

Negative

64 (50.4)

56 (87.5)

6 (9.4)

2 (3.1)

Not available

39 (30.7)

33 (84.6)

2 (5.1)

4 (10.3)

  1. HNPCC, hereditary nonpolyposis colorectal cancer fulfilling the Amsterdam criteria; suspected HNPCC, one or more first-degree relatives with colorectal or HNPCC-related tumors, and early-onset colorectal cancer or multiple large bowel adenocarcinomas; positive, one first-degree relative affected by colorectal cancer; negative, no first-degree relatives affected by colorectal cancer.
Back to article page