FIGURE 2

Immunohistochemical analysis of chronic sclerosing sialadenitis of the submandibular gland. A, intraepithelial and periductal T cells in the early phase of Küttner tumor. CD3 staining, Strept-ABC method, 400×. B, cytoplasmatic granzyme B staining of intra- and periepithelial cytotoxic T cells. APAAP method, 200×. C, germinal center formation and intraepithelial B cells in the late phase of Küttner tumor. CD20 staining, APAAP method, 50×. D, intraepithelial B cells and salivary duct in Küttner tumor. CD20 staining, APAAP method, 100×. E, epithelioid cells and Langhans' giant cells in the late phase of Küttner tumor. Ki-M1P staining, APAAP method, 200×. F, plasmacytoid monocytes and macrophages in the middle phase of Küttner tumor. Ki-M1P staining, APAAP method, 200×.