TABLE 1 Staging System for Chronic Sclerosing Sialadenitis of the Submandibular Gland (11)

1

Focal periductal lymphocytic infiltration and slight increase in duct diameter

2

Increasing periductal lymphocyte infiltration, lymph follicle formation, focal metaplasia with proliferation of ductal epithelium, inspissated ductal secretion, interstitial fibrosis, and beginning atrophy of acini

3

Intensive diffuse lymphocytic infiltration, periductal and intralobular lymph follicle formation, periductal hyalinization and sclerosis, accentuated metaplasia of ductal epithelium, and parenchymal atrophy

4

Fibrocytic destruction of lobular architecture, resulting in marked parenchymal loss and sclerosis