TABLE 3 Immunohistochemical Staining and FISH Results in Cases of PL/DLCIS and PLCIS with Invasive Carcinomaa

From: Clinical, Histopathologic, and Biologic Features of Pleomorphic Lobular (Ductal-Lobular) Carcinoma In Situ of the Breast: A Report of 24 Cases

Characteristic

PL/DLCIS (%)

PLCIS with Invasion (%)

ER staining

10/10 (100)

14/14 (100)

p53 staining

3/10 (30)

4/14 (29)

E-cadherin staining

0/10 (0)

0/14 (0)

HER-2/neu amplification

0/10 (0)

1/13 (8)

GCDFP-15 stainingb

8/9 (89)

6/10 (60)

Proliferation ratec

  

 Low

5/9 (56)

4/8 (50)

 Moderate

2/9 (22)

2/8 (25)

 High

2/9 (22)

2/8 (25)

  1. aData are the numbers of positive cases/numbers of cases tested.
  2. bThe percentages of positive cells were 20%–90% in PL/DLCIS cases and 5%–70% in PLCIS cases with invasion.
  3. cLow, <10% positive tumor-cell nuclei; moderate, 10%–20% positive tumor-cell nuclei; high, >20% positive tumor-cell nuclei.
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