FIGURE 1

Chromosome 1 imbalances detected by CGH. The mean ratio profile of 22–24 analyzed chromosomes (n = 22–24) is depicted with the 95% confidence interval (gold lines). Red and green lines represent thresholds for the chromosomal losses (0.75) and gains (1.25), respectively. A, case H3. Loss of entire p-arm and high-level gain of the entire q-arm were suggested. B, case H14 displayed regional loss of p-arm at 1p33-pter and low-level copy number gain of the entire q-arm. C, Case H30, absence of p-arm imbalances and regional amplification of 1q21–q25 were indicated.