FIGURE 2 | Modern Pathology

FIGURE 2

From: Germline APC Mutation on the β-Catenin Binding Site Is Associated with a Decreased Apoptotic Level in Colorectal Adenomas

FIGURE 2

Differences in the PCD level correlated with mutations on the β-catenin–binding/degradation sites. A, B, adenomas from mutation on codon 912 with the presence of a high number of Leuchtenberger bodies (+++; arrow; A) and from APC mutation 1383 characterized by few Leuchtenberger bodies (+; arrow; B); H&E staining, magnification, 40 ×. C, D, sections from the same adenomas analyzed by the TUNEL technique, showing high levels of PCD activation for mutation on codon 912 (C) and low levels for MT-1383 (D); weakly counterstained with methyl green, magnification, 40 ×.

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