TABLE 1 Clinical and Molecular Features of Five Patients with Pure Dysplasia or Carcinoma In Situ

From: Immunohistochemical and Genetic Analysis of Non–Small Cell and Small Cell Gallbladder Carcinoma and Their Precursor Lesions

Case Number

Age

Sex

Stone

p53

Dpc4

p16

pRB

K-ras

1 (LGD)

39

M

Yes

NL

NL

NL

NL

NL

2 (LGD)

37

F

Yes

NL

NL

NL

NL

NL

3 (CIS)

71

M

No

OE

NL

LOSS

NL

MUT D (Val)

4 (CIS)

63

F

Yes

OE

NL

LOSS

NL

NL

5 (CIS)

57

F

Yes

OE

NL

LOSS

NL

NL

  1. NL = normal pattern (intact labeling for p16, Dpc4, and pRB, less than 30% expression of p53, wild type K-ras); OE = overexpression; LOSS = loss of expression; LGD = low-grade dysplasia; CIS = carcinoma in situ; MUT = K-ras mutation; Stone = gallstone present in specimen.
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