TABLE 1 Criteria for NAD Grading
From: Grading of Atypia in Nevi: Correlation with Melanoma Risk
Characteristic | CMN-Not Atypical | NAD-Mild | NAD-Mod | NAD-Severe | Melanoma |
|---|---|---|---|---|---|
Lateral circumscription | Sharp | Slightly diminished | Moderate | Moderate | Poor |
Symmetry | Good | Good | Good | Often broken | Rare |
Junctional extension | Unusual | Usual | Usual | Usual | Extensive |
Rete ridge distortion | Occasional | Occasional | Usual | Always | Occasional |
Fibrosis | Regressive | Often | Always | Always | Occasional |
Melanocyte distribution | Nests dispersed | Nests dispersed | Nests dispersed | Nests dispersed | Dispersed nests |
Upward migration | Occasionally centrally | Rarely | Occasionally centrally | Occasional centrally | Often central and peripheral |
Suprapapillary plates | Spared | Spared | Usually spared | Often involved | Involved |
Nuclear size | Age-related | Small | Medium | Large | Medium/large |
Nucleoli | Age-related | Small | Medium | Large | Large |
Chromatin | Uniform | Condensed | Partially expanded | Expanded, coarse in some cells | Expanded, hyperchromatic and coarse |
Mitoses/dermal | Few superficial | Few superficial | Few superficial | Few superficial | Superficial and deep mitoses |
