FIGURE 5
From: Early Acquisition of Gelatinolytic Activity in Carcinogenesis of the Uterine Cervix
Immunohistochemical staining of matrix metalloproteinase-2 and MIB-1 in invasive cervical carcinoma. (A, B: original magnification, 100×). Paraffin sections were immunostained with monoclonal antibodies against matrix metalloproteinase-2 (A) and Ki-67 (B). Note that MIB-1 protein was localized in the nuclei of the nonkeratinizing cancer cells, whereas matrix metalloproteinase-2 protein was observed diffusely in surrounding stromal tissues. This case showed the homogenous pattern in film in situ zymography.
