TABLE 1 Result of Film In Situ Zymography and Immunohistochemistrical Result of Matrix Metalloproteinase-2 and MIB-1 Index

From: Early Acquisition of Gelatinolytic Activity in Carcinogenesis of the Uterine Cervix

 

Number of cases

Number of HEP (%)

Number of HOP (%)

MMP-2

MIB-1 Index

Invasive cancer

8

0 (0)

8 (100)

4/8

33.8

CIN 3

 CIS

14

8 (57)

6 (43)

0/14

17.6

 SD

5

2 (40)

0 (0)

0/5

7.0

CIN 2

5

3 (60)

0 (0)

0/5

8.9

CIN 1

5

0 (0)

0 (0)

0/5

0

Nontumorous lesion

13

3 (23)

0 (0)

0/13

1.0

  1. CIN, cervical intraepithelial neoplasia; CIS, Carcinoma in situ; SD, severe dysplasia; HEP, heterogenous pattern; HOP, homogenous pattern; MMP-2, matrix metaloproteinase-2; MIB-1 index, average number of the stained cells/100 counted cell.