Abstract
We report here that applying genetic vectors onto the skin in a relatively non-invasive manner can elicit an immune response against the protein encoded by the vector. This procedure requires no special skill or equipment and so may reduce medical costs and offer a unique method for vaccination.
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References
Johnston, S. A. & Tang, D.-c. Meth. Cell Biol. 43, 353–365 (1994).
Tang, D.-c., Johnston, S. A. & Carbone, D. P. Cancer Gene Ther. 1, 15–20 (1994).
Tang, D.-c., DeVit, M. & Johnston, S. A. Nature 356, 152–154 (1992).
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Tang, Dc., Shi, Z. & Curiel, D. Vaccination onto bare skin. Nature 388, 729–730 (1997). https://doi.org/10.1038/41917
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DOI: https://doi.org/10.1038/41917
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