Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Pigment chemistry

The red sweat of the hippopotamus

The red and orange pigments in this secretion account for its protective properties.

Abstract

Cool customer: hippos create their own antibiotic sunscreen. Credit: P. JOHNSON/CORBIS

Within a few minutes of perspiration, the colourless, viscous sweat of the hippopotamus gradually turns red, and then brown as the pigment polymerizes. Here we isolate and characterize the pigments responsible for this colour reaction. The unstable red and orange pigments turn out to be non-benzenoid aromatic compounds that are unexpectedly acidic and have antibiotic as well as sunscreen activity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structures of the red and orange pigments isolated from hippopotamus sweat.

Similar content being viewed by others

References

  1. Eltringham, S. K. The Hippos 8–38 (Poyser Natural History Series, London, 1999).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kimiko Hashimoto.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Methods (DOC 49 kb)

Supplementary Figure 1

UV-VIS spectrum of hipposudoric acid (JPG 23 kb)

Supplementary Figure 2

UV-VIS spectrum of norhipposudoric acid (JPG 24 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Saikawa, Y., Hashimoto, K., Nakata, M. et al. The red sweat of the hippopotamus. Nature 429, 363 (2004). https://doi.org/10.1038/429363a

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/429363a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing