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Molecular medicine

Lost in translation

A mysterious disease that causes children's brains to melt away is caused by errors in RNA translation. But biologists are realizing that this horrifying condition could shed light on more common problems. Claire Ainsworth reports.

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References

  1. Hanefeld, F. et al. Neuropediatrics 24, 244–248 (1993).

    Article  CAS  Google Scholar 

  2. Schiffmann, R. et al. Ann. Neurol. 35, 331–340 (1994).

    Article  CAS  Google Scholar 

  3. van der Knaap, M. S. et al. Neurology 48, 845–855 (1997).

    Article  CAS  Google Scholar 

  4. Leegwater, P. A., Pronk, J. C. & van der Knaap, M. S. J. Child Neurol. 18, 639–645 (2003).

    Article  Google Scholar 

  5. van der Knaap, M. S. et al. Ann. Neurol. 51, 264–270 (2002).

    Article  CAS  Google Scholar 

  6. Leegwater, P. A. J. et al. Nature Genet. 29, 383–388 (2001).

    Article  CAS  Google Scholar 

  7. Abbott, C. M. & Proud, C. G. Trends Biochem. Sci. 29, 25–31 (2004).

    Article  CAS  Google Scholar 

  8. Li, W., Wang, X., van der Knaap, M. S. & Proud, C. G. Mol. Cell. Biol. 24, 3295–3306 (2004).

    Article  CAS  Google Scholar 

  9. Lazaris-Karatzas, A., Montine, K. S. & Sonenberg, N. Nature 345, 544–547 (1990).

    Article  ADS  CAS  Google Scholar 

  10. De Benedetti, A. & Graff, J. R. Oncogene 23, 3189–3199 (2004).

    Article  CAS  Google Scholar 

  11. Stoneley, M. & Willis, A. E. Oncogene 23, 3200–3207 (2004).

    Article  CAS  Google Scholar 

  12. Bjornsti, M. -A. & Houghton, P. J. Nature Rev. Cancer 4, 335–348 (2004).

    Article  CAS  Google Scholar 

  13. Fogli, A. et al. Am. J. Hum. Genet. 72, 1544–1550 (2003).

    Article  CAS  Google Scholar 

  14. Fogli, A. et al. BMC Women's Health 4, doi:10.1186/1472-6874-4-8 (2004).

    Google Scholar 

  15. Fogli, A. et al. Ann. Neurol. 52, 506–510 (2002).

    Article  CAS  Google Scholar 

  16. van der Knaap, M. S. et al. Am. J. Hum. Genet. 73, 1199–1207 (2003).

    Article  CAS  Google Scholar 

Download references

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  1. Claire Ainsworth is a senior news & features editor for Nature.

    • Claire Ainsworth
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Ainsworth, C. Lost in translation. Nature 435, 556–558 (2005). https://doi.org/10.1038/435556a

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