Abstract
My interest in protein breakdown as a research problem began in 1955. In 1963, when we relocated from Yale to the Institute for Cancer Research of Fox Chase, Philadelphia, nothing new was being reported. Here, I review how we get the ubiquitin proteasome system all together.
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Abbreviations
- APF-1:
-
ATP-dependent proteolysis factor 1
- DUB:
-
deubiquitinating enzyme
- UCH:
-
Ub-carboxy-terminal hydrolase
References
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See previous autobiographical chapter
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Acknowledgements
It is a pleasure to pay tribute to Dr. Avram Hershko, whose analytic intuition was always productive and whose generous spirit made our interactions always harmonious. The post-docs: Aaaron Ciehanover, Art Haas, Cecile Pickart, and Keith Wilkinson were all major contributors who have continued their careers in the Ub field with notable success. Thanks are also due to Hannah Heller and Jesse Warms for their contributions in the lab. This review was obtained thanks to the kind help of the Nobel Foundation in Stockholm, http://nobelprize.org (© The Nobel Foundation 2004).
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Edited by G Melino
Nobel Lecture 2004, © The Nobel Foundation 2004
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Rose, I. Ubiquitin at Fox Chase. Cell Death Differ 12, 1198–1201 (2005). https://doi.org/10.1038/sj.cdd.4401710
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DOI: https://doi.org/10.1038/sj.cdd.4401710
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