Figure 1
From: Discovery of the ubiquitin proteasome system and its involvement in apoptosis
Timeline of the discovery of the UPS. The diagram shows sum of the pivotal discoveries and milestones that historically lead to the identification of the UPS intracellular protein degradation. Owing to obvious space limitation, it is not possible to provide the necessary credit to all scientists and discoveries involved. At present, several diseases related to protein misfolding and defect in protein degradation have been identified, and specific inhibitors of the UPS are now in clinical trials
