Table 1 Lipophilic statins decrease cell viability in human osteosarcoma cells with different phenotypic characteristics

From: RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation

 

MG63

U2OS

CAL-72

Atorvastatin

77±3*

85±1*

72±3*

Cerivastatin

81±2*

77±1*

86±1*

Simvastatin

83±2*

97±2

76±4*

  1. Statins were tested at a concentration of 10 μM. Data are expressed as percentage of values in untreated cells (mean±S.E.M., n=8)
  2. *P<0.05 versus untreated cells
Back to article page