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Interpretation of the ALLHAT interim analysis and implications for the treatment of patients with BPH

Prostate Cancer and Prostatic Diseases volume 3, pages 152–156 (2000)Cite this article

Abstract

The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was designed to see if the effects of doxazosin, amlodipine and lisinopril were superior to those of chlorthalidone on the incidence of cardiovascular disease in high-risk patients with hypertension. Earlier this year, following an interim analysis of 24,335 patients, the doxazosin treatment arm was stopped amid reports of an increased incidence of secondary cardiovascular endpoints relative to chlorthalidone. This paper will offer some insight into the interpretation of the ALLHAT interim data, and clarify any issues around the use of alpha-1 adrenoceptor antagonists, such as doxazosin, in the management of patients with benign prostatic hyperplasia.

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Authors and Affiliations

  1. Department of Urology, St George’s Hospital, Blackshaw Road, London, UK

    RS Kirby

  2. Departments of Medicine and Pharmacology, Baylor College of Medicine, Houston, Texas, USA

    JL Pool

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  1. RS Kirby
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  2. JL Pool
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Correspondence to RS Kirby.

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Kirby, R., Pool, J. Interpretation of the ALLHAT interim analysis and implications for the treatment of patients with BPH. Prostate Cancer Prostatic Dis 3, 152–156 (2000). https://doi.org/10.1038/sj.pcan.4500475

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  • DOI: https://doi.org/10.1038/sj.pcan.4500475

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