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Distribution of vascular endothelial growth factor (VEGF) in prostate disease

Prostate Cancer and Prostatic Diseases volume 5, pages 119–122 (2002)Cite this article

Abstract

Vascular endothelial growth factor (VEGF) is a heparin-binding polypeptide growth factor. It is a potent mitogen for endothelial cells. Immunohistochemical localisation of VEGF was performed on 25 moderate to poorly differentiated stage T4 M+ prostate cancer specimens and 30 benign prostatic hyperplasia (BPH) specimens. A positive result was indicated by area staining >25% and +2 or +3 staining intensity. Positive epithelial staining was observed in 50% of BPH specimens and 56% of cancer specimens, while positive stromal staining was observed in 73% of BPH specimens and 30% of cancer specimens. This may reflect an active role for stromal VEGF in the pathological process of BPH.

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Acknowledgements

We would like to thank the Istabraq Cancer Research fund for their financial support.

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Authors and Affiliations

  1. Departments of Pathology and Urology, Kings College Hospital, London, UK

    K Walsh, S Sriprasad, D Hopster, J Codd & D Mulvin

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  1. K Walsh
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  2. S Sriprasad
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  3. D Hopster
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  4. J Codd
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  5. D Mulvin
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Correspondence to K Walsh.

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Walsh, K., Sriprasad, S., Hopster, D. et al. Distribution of vascular endothelial growth factor (VEGF) in prostate disease. Prostate Cancer Prostatic Dis 5, 119–122 (2002). https://doi.org/10.1038/sj.pcan.4500575

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